Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2.

OBJECTIVE: The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission. METHODS: This study was a single-center prospective cohort. Data were collected from medical records of pediatric inpatients with sickle cell disease under 18 years old infected or not with SARS-CoV-2 from the first visit to the hospital until discharge and from the last medical appointment. All patients were tested for SARS-CoV-2 by the real-time reverse transcription polymerase chain reaction. RESULTS: Among 57 pediatric patients with sickle cell disease hospitalized from March to November 2020 in a Brazilian academic hospital, 11 (19.3%) had a positive result for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities than the ones who were not infected (63.6 vs. 30.4%; p=0.046). During hospital stay, no clinical or complete blood count differences between groups were found. There was a decrease in eosinophil count on hospital admission in patients with sickle cell disease infected by SARS-CoV-2 (p=0.008). CONCLUSIONS: Pediatric hospitalized patients with sickle cell disease infected by SARS-CoV-2 had more comorbidities and had a decrease in eosinophil count between hospital admission and the last medical appointment.

Clinical and laboratory differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 / Diferenças clínicas e laboratoriais entre pacientes pediátricos hospitalizados com doença falciforme infectados ou não por SARS-CoV-2

Abstract Objective: The aim of this study was to identify clinical and complete blood count differences between pediatric hospitalized patients with sickle cell disease infected or not by SARS-CoV-2 and compare the complete blood count of patients with sickle cell disease infected by SARS-CoV-2 before hospitalization and on admission. Methods: This study was a single-center prospective cohort. Data were collected from medical records of pediatric inpatients with sickle cell disease under 18 years old infected or not with SARS-CoV-2 from the first visit to the hospital until discharge and from the last medical appointment. All patients were tested for SARS-CoV-2 by the real-time reverse transcription polymerase chain reaction. Results: Among 57 pediatric patients with sickle cell disease hospitalized from March to November 2020 in a Brazilian academic hospital, 11 (19.3%) had a positive result for SARS-CoV-2. Patients infected by SARS-CoV-2 had a higher prevalence of comorbidities than the ones who were not infected (63.6 vs. 30.4%; p=0.046). During hospital stay, no clinical or complete blood count differences between groups were found. There was a decrease in eosinophil count on hospital admission in patients with sickle cell disease infected by SARS-CoV-2 (p=0.008). Conclusions: Pediatric hospitalized patients with sickle cell disease infected by SARS-CoV-2 had more comorbidities and had a decrease in eosinophil count between hospital admission and the last medical appointment.

RESUMO Objetivo: Identificar diferenças clínicas e laboratoriais entre pacientes pediátricos hospitalizados com doença falciforme infectados ou não por SARS-CoV-2 e comparar o hemograma completo de pacientes com doença falciforme infectados por SARS-CoV-2 antes da hospitalização e durante a admissão. Métodos: Coorte prospectiva unicêntrica, cujos dados foram coletados em prontuários de pacientes pediátricos internados com doença falciforme, menores de 18 anos, infectados ou não com SARS-CoV-2, desde a primeira visita ao hospital até a alta e desde a última consulta médica. Todos os pacientes foram testados para SARS-CoV-2 pela transcrição reversa seguida de reação em cadeia da polimerase em tempo real. Resultados: Dos 57 pacientes pediátricos com doença falciforme internados de março a novembro de 2020 em um hospital universitário brasileiro, 11 (19,3%) apresentaram resultado positivo para SARS-CoV-2. Pacientes infectados pelo SARS-CoV-2 apresentaram maior prevalência de comorbidades do que aqueles não infectados (63,6 vs. 30,4%; p=0,046). Durante a internação hospitalar, não foram encontradas diferenças clínicas ou laboratoriais entre os grupos. Houve diminuição da contagem de eosinófilos na admissão hospitalar em pacientes com doença falciforme infectados pelo SARS-CoV-2 (p=0,008). Conclusões: Pacientes pediátricos hospitalizados com doença falciforme infectados pelo SARS-CoV-2 apresentaram mais comorbidades e diminuição da contagem de eosinófilos entre a admissão hospitalar e a última consulta médica.

Fraturas: perfil da população infanto-juvenil internada em um Hospital Escola do interior paulista / Fracturas: perfil de la población infanto-juvenil, ingresados en un Hospital Escuela en el interior de São Paulo / Fractures: profile of children and youth population admitted at a School Hospital of inside São Paulo State

Introdução: As fraturas representam 10 a 25% dos traumatismos da população infanto-juvenil, mas existem poucos dados sobre as queexigem cuidados hospitalares. Objetivos: Descrever o perfil da população infanto-juvenil, vítima de fratura, internada em um hospital escolado interior paulista e comparar os resultados com dados existentes na literatura. Material e Método: Estudo transversal, retrospectivo,que revisou 548 prontuários de casos de fratura em menores de 20 anos, internados no Hospital Padre Albino, de Catanduva-SP, dejaneiro/2011 a dezembro/2014. As variáveis analisadas foram: dados demográficos e peculiaridades do trauma sofrido. Os resultadosforam expressos em número, porcentagem e média. Resultados: 379 prontuários foram selecionados para participar da pesquisa, commédia de idade de 11,3 anos, sendo 73,1% do sexo masculino. Dos casos com informações disponíveis, 53% residiam em Catanduva;76,7% dos acidentes aconteceram nas vias de trânsito; as quedas representaram 68,2% dos mecanismos causadores; 98% dos pacientesforam admitidos conscientes; 3,3% necessitaram de terapia intensiva; 73,3% foram fraturas de membros superiores; 85% receberamtratamento...

Introduction: Fractures represent 10-25% of injuries among children and adolescents, but there are few data about those requiringhospital cares. Objectives: To describe the profile of children and adolescents affected with fracture admitted to a school hospital insideSão Paulo State and compare the results with literature data. Material and Method: Our Cross-sectional, retrospective study reviewed 548records of fracture cases in patients under 20 admitted to the Hospital Padre Albino, Catanduva-SP, from January/2011 to December/2014.The variables analyzed were: demographics and suffered trauma peculiarities. The results were expressed in terms of number, percentageand average. Results: We selected 379 charts to be included in the study, with patients of a mean age of 11.3 years, being 73.1% male.Considering the cases with available information, 53% lived in Catanduva; 76.7% of the accidents occurred in the transit routes; fallsaccounted for 68.2% of the causal mechanisms; 98% of patients were admitted aware; 3.3% required intensive care; 73.3% werefractures of the upper limbs; 85% received surgical treatment; the average time of stay was 4.0 days and 96.5% were discharged withoutphysical sequel. Conclusion: Males are the main victims of fractures; most accidents occur on public roads; falls are main causative agents;upper limbs fractures...

Introducción: Las fracturas representan el 10-25% de las lesiones de los niños y adolescentes, pero hay pocos datos sobre los querequieren atención hospitalaria. Objetivos: Describir el perfil de los niños y adolescentes, víctimas de fracturas ingresados en un hospital.Métodos: Transversal, retrospectivo que revisó los registros de 548 casos de fracturas en niños menores de 20 años ingresados en elHospital Padre Albino, Catanduva-SP, a partir de enero 2011 a diciembre/2014. Las variables analizadas fueron: datos demográficos ypeculiaridades del traumatismo. Los resultados se expresaron como el número y el porcentaje de la media. Resultados: Se seleccionaron379 registros para participar en el estudio, con una media de edad de 11,3 años, 73,1% hombres. Los casos com información disponible,el 53% vivían en Catanduva; 76,7% de los accidentes se produjo en las rutas de tránsito; caídas representaron el 68,2% de losmecanismos causales; 98% de los pacientes fueron admitidos encuenta; 3,3% requiere de cuidados intensivos; 73,3% eran fracturas delas extremidades superiores...